Klaus Schaffler Selected Research

Hyperalgesia

8/2012	Dose-response relationship after single oral dose administrations of morphine and oxycodone using laser-evoked potentials on UVB- and capsaicin-irritated skin in healthy male subjects.
4/2009	Predicting therapeutic efficacy - experimental pain in human subjects.
1/2005	Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials from capsaicin-induced hyperalgesic human skin.
1/2004	Effect of the new H1-antagonist ReN1869 on capsaicin-induced hyperalgesia in human skin/Human phase-I trial using somatosensory evoked potentials induced by a CO2 laser.
1/2004	Analgesic effects of low-dose intravenous orphenadrine in the state of capsaicin hyperalgesia. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory evoked potentials obtained from capsaicin-irritated skin in healthy volunteers.

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Klaus Schaffler Research Topics

Disease

9	Pain (Aches) 11/2018 - 01/2004
5	Hyperalgesia 08/2012 - 01/2004
3	Neurogenic Inflammation 01/2005 - 01/2004
1	Neuralgia (Stump Neuralgia) 01/2017
1	Schizophrenia (Dementia Praecox) 03/2006
1	Cognitive Dysfunction 03/2006
1	Fatigue 01/2004
1	Vertigo (Positional Vertigo) 01/2002
1	Motion Sickness (Airsickness) 01/2002

Drug/Important Bio-Agent (IBA)

8	Capsaicin (Zostrix)FDA Link 11/2018 - 01/2004
4	SolutionsIBA 08/2012 - 01/2004
2	Pregabalin (Lyrica)FDA Link 11/2018 - 01/2017
2	Analgesics (Analgesic Drugs)IBA 01/2005 - 01/2004
2	Orphenadrine (Disipal)FDA LinkGeneric 01/2005 - 01/2004
1	ASP8477IBA 01/2018
1	Celecoxib (Celebrex)FDA Link 01/2017
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 01/2017
1	Lacosamide FDA Link 01/2017
1	ABT 102IBA 02/2013
1	Morphine (MS Contin)FDA LinkGeneric 08/2012
1	Oxycodone (Oxycontin)FDA LinkGeneric 08/2012
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/2009
1	Opiate AlkaloidsIBA 04/2009
1	EsketamineIBA 03/2006
1	Hypericum extract LI 160IBA 03/2006
1	Ketamine FDA LinkGeneric 03/2006
1	Excitatory Amino Acid AntagonistsIBA 03/2006
1	NeodolpasseIBA 01/2005
1	Diclofenac (SR 38)FDA LinkGeneric 01/2005
1	GlucocorticoidsIBA 01/2004
1	TabletsIBA 01/2002
1	Chewing Gum (Chewing Gums)IBA 01/2002
1	SodiumIBA 01/2002
1	Dimenhydrinate (DMH)FDA LinkGeneric 01/2002

Therapy/Procedure

4	Lasers (Laser) 02/2013 - 01/2004
3	Gas Lasers 01/2005 - 01/2004
1	Therapeutics 04/2009
1	Intravenous Infusions 01/2004
1	Telescopes 01/2002